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Negative / Null Result ReportOpen accessMedicine· cited by 407

Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial

David R. Mandel; Katy Eichas; J Holmes · 2010 · BMC Complementary and Alternative Medicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Lactic acid-producing bacteria (LAB) probiotics demonstrate immunomodulating and anti-inflammatory effects and the ability to lessen the symptoms of arthritis in both animals and humans. This randomized, double-blind, placebo-controlled, parallel-design, clinical pilot trial was conducted to evaluate the effects of the LAB probiotic preparation, Bacillus coagulans GBI-30, 6086, on symptoms and measures of functional capacity in patients with rheumatoid arthritis (RA) in combination with pharmacological anti-arthritic medications. METHODS: Forty-five adult men and women with symptom

Abstract by David R. Mandel; Katy Eichas; J Holmes, BMC Complementary and Alternative Medicine (2010) — licensed CC BY 4.0.

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Metadata source: OpenAlex · DOI 10.1186/1472-6882-10-1