Replication FailureOpen accessMedicine· cited by 10

Genome-wide association study of idiopathic pulmonary fibrosis susceptibility using clinically curated European ancestry datasets

Daniel Chin; Tamara Hernández-Beeftink; Lauren J. Donoghue; Beatriz Guillén‐Guío; Olivia C. Leavy; Ayodeji Adegunsoye; Helen Booth; CleanUP-IPF Investigators of the Pulmonary Trials Cooperative · 2026 · European Respiratory Journal

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract

ABSTRACT Background Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease that might represent potential new drug targets, and it has been shown that drug targets with support from genetic studies are more likely to be successful in clinical development. Previous genome-wide association studies (GWAS) of IPF susceptibility have identified more than 20 signals implicating genes involved in multiple mechanisms, including telome

Abstract by Daniel Chin; Tamara Hernández-Beeftink; Lauren J. Donoghue; Beatriz Guillén‐Guío; Olivia C. Leavy; Ayodeji Adegunsoye; Helen Booth; CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, European Respiratory Journal (2026) — licensed CC BY 4.0.

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