Negative / Null Result ReportOpen accessMedicine· cited by 40

Switching HIV Treatment in Adults Based on CD4 Count Versus Viral Load Monitoring: A Randomized, Non-Inferiority Trial in Thailand

Gonzague Jourdain; Sophie Le Cœur; Nicole Ngo‐Giang‐Huong; Patrinee Traisathit; Tim R. Cressey; Federica Fregonese; Baptiste Leurent; Intira Jeannie Collins · 2013 · PLoS Medicine

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

BACKGROUND: Viral load (VL) is recommended for monitoring the response to highly active antiretroviral therapy (HAART) but is not routinely available in most low- and middle-income countries. The purpose of the study was to determine whether a CD4-based monitoring and switching strategy would provide a similar clinical outcome compared to the standard VL-based strategy in Thailand. METHODS AND FINDINGS: The Programs for HIV Prevention and Treatment (PHPT-3) non-inferiority randomized clinical trial compared a treatment switching strategy based on CD4-only (CD4) monitoring versus viral-load (VL

Abstract by Gonzague Jourdain; Sophie Le Cœur; Nicole Ngo‐Giang‐Huong; Patrinee Traisathit; Tim R. Cressey; Federica Fregonese; Baptiste Leurent; Intira Jeannie Collins, PLoS Medicine (2013) — licensed CC BY 4.0.

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