Genetic variants associated with sepsis-associated acute kidney injury.
Nicholas J Douville; Lisa Bastarache; Emily Bertucci-Richter; Snehal Patil; Elizabeth S Jewell; Robert E Freundlich; Miklos D Kertai; Milo C Engoren · 2024 · PLoS ONE
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Abstract
Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin
Abstract by Nicholas J Douville; Lisa Bastarache; Emily Bertucci-Richter; Snehal Patil; Elizabeth S Jewell; Robert E Freundlich; Miklos D Kertai; Milo C Engoren, PLoS ONE (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0311318