Cortical development dynamics across autism spectrum disorder mouse models
Lena A. Schwarz; Christoph P. Dotter; Sergey V. Isaev; Michela Lisi; Daniel Malzl; Christoph Bueschl; Sabrina Ladstätter; Bárbara Oliveira · 2026 · Nature
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations converged on perturbations of the radial glial cell lineage. These alterations reflect a transient developmental delay rather than lasting lineage misspecification and resolve by postnatal stages. Molecularly, the largest transcriptional differences e
Abstract by Lena A. Schwarz; Christoph P. Dotter; Sergey V. Isaev; Michela Lisi; Daniel Malzl; Christoph Bueschl; Sabrina Ladstätter; Bárbara Oliveira, Nature (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41586-026-10679-1