Negative / Null Result ReportOpen accessMedicine· cited by 19

Evaluation of the human adaptation of influenza A/H7N9 virus in PB2 protein using human and swine respiratory tract explant cultures

Louisa Chan; Christine T. H. Bui; Chris Ka Pun Mok; Mandy M.T. Ng; John M. Nicholls; Malik Peiris; Michael C. W. Chan; Renee W. Y. Chan · 2016 · Scientific Reports

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Novel avian H7N9 virus emerged in China in 2013 resulting in a case fatality rate of around 39% and continues to pose zoonotic and pandemic risk. Amino acid substitutions in PB2 protein were shown to influence the pathogenicity and transmissibility of H7N9 following experimental infection of ferrets and mice. In this study, we evaluated the role of amino acid substitution PB2-627K or compensatory changes at PB2-591K and PB2-701N, on the tropism and replication competence of H7N9 viruses for human and swine respiratory tracts using ex vivo organ explant cultures. Recombinant viruses of A/Shangh

Abstract by Louisa Chan; Christine T. H. Bui; Chris Ka Pun Mok; Mandy M.T. Ng; John M. Nicholls; Malik Peiris; Michael C. W. Chan; Renee W. Y. Chan, Scientific Reports (2016) — licensed CC BY 4.0.

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