Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy
William W. Ho; Igor L. Gomes‐Santos; Shuichi Aoki; Meenal Datta; Kosuke Kawaguchi; Nilesh P. Talele; Sylvie Roberge; Jun Ren · 2021 · Proceedings of the National Academy of Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Liver metastasis is a major cause of mortality for patients with colorectal cancer (CRC). Mismatch repair-proficient (pMMR) CRCs make up about 95% of metastatic CRCs, and are unresponsive to immune checkpoint blockade (ICB) therapy. Here…
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Metadata source: OpenAlex · DOI 10.1073/pnas.2105323118