Induction TPF followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locally advanced hypopharyngeal cancer: a preliminary analysis of a randomized phase 2 trial
Xi Luo; Xiaodong Huang; Jingwei Luo; Jianping Xiao; Kai Wang; Yuan Qu; Xuesong Chen; Ye Zhang · 2022 · BMC Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
PURPOSE: Concurrent chemoradiotherapy (CCRT) is a standard treatment choice for locally advanced hypopharyngeal carcinoma. The aim of this study was to investigate whether induction chemotherapy (IC) followed by CCRT is superior to CCRT alone to treat locally advanced hypopharyngeal carcinoma. METHODS AND MATERIALS: Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS),
Abstract by Xi Luo; Xiaodong Huang; Jingwei Luo; Jianping Xiao; Kai Wang; Yuan Qu; Xuesong Chen; Ye Zhang, BMC Cancer (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12885-022-10306-y