Mycophenolic acid pharmacogenomics in kidney transplantation
Fabiana Dalla Vecchia Genvigir; Álvaro Cerda; Thiago Dominguez Crespo Hirata; Mário Hiroyuki Hirata; Rosário Dominguez Crespo Hirata · 2020 · Journal of Translational Genetics and Genomics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mycophenolic acid (MPA) is a potent antiproliferative drug prescribed to prevent acute rejection in kidney transplantation. MPA reversibly inhibits the enzymes involved in the synthesis of guanosine nucleotides, thus preventing DNA replication of immune cells. Consequently, the repression of both cell and humoral immunity induces renal allograft tolerance. MPA is an effective and safe immunosuppressive drug, but some patients show variability in drug concentration, acute rejection, graft dysfunction, or MPA-related adverse events. Although the pharmacogenomics of immunosuppressive drugs has be
Abstract by Fabiana Dalla Vecchia Genvigir; Álvaro Cerda; Thiago Dominguez Crespo Hirata; Mário Hiroyuki Hirata; Rosário Dominguez Crespo Hirata, Journal of Translational Genetics and Genomics (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.20517/jtgg.2020.37