Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study
Magnus Lindskog; Anna Laurell; Anders Kjellman; Bohuslav Melichar; Pablo Maroto Rey; Henryk Zieliński; Felipe Villacampa; Pierre Bigot · 2022 · European Urology Open Science
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: The prognosis of patients with synchronous metastatic renal cell carcinoma (mRCC) is poor. Whereas single-agent tyrosine kinase inhibition (TKI) is clearly insufficient, the effects can be enhanced by combinations with immune checkpoint inhibitors. Innovative treatment options combining TKI and other immune-stimulating agents could prove beneficial. Objective: To evaluate the clinical effects on metastatic disease when two doses of allogeneic monocyte-derived dendritic cells (ilixadencel) are administrated intratumorally followed by nephrectomy and treatment with sunitinib compared
Abstract by Magnus Lindskog; Anna Laurell; Anders Kjellman; Bohuslav Melichar; Pablo Maroto Rey; Henryk Zieliński; Felipe Villacampa; Pierre Bigot, European Urology Open Science (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.euros.2022.03.012