Negative / Null Result ReportOpen accessMedicine· cited by 9

Metabolic dysfunction and mitochondrial failure in Alzheimer's disease: integrating pathophysiology, clinical evidence and emerging interventions

Xiaohua Xiao; Xueqin Yan; Chunhua Liang; Yunzhu Yang · 2026 · Frontiers in Neurology

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Alzheimer's disease (AD) is a gradual and irreversible decline in the brain's ability to function which is not only signified by amyloid-beta plaques and neurofibrillary tangles but also by and metabolic and mitochondrial changes that have a negative impact on the classical neuropathological hallmarks. It is becoming increasingly clear that the central roles in the process of synaptic dysfunction, neuronal death and cognitive decline are played by the brain's impaired glucose utilization, insulin resistance, lipid metabolism alterations, and energy homeostasis disruption. Mitochondrial dysfunc

Abstract by Xiaohua Xiao; Xueqin Yan; Chunhua Liang; Yunzhu Yang, Frontiers in Neurology (2026) — licensed CC BY 4.0.

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