Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment
Xiaofeng Dai; Chongxiang Wang; Ping Jiang; Xiaopeng Mei · 2026 · MedComm
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Chronic pain is a globally prevalent and complex condition, encompassing three primary subtypes, that is, nociceptive, neuropathic, and nociplastic, each with distinct biopsychosocial mechanisms. Chronic pain was historically viewed as a monolithic symptom and managed with opioid-centric models, causing widespread therapeutic failure. While recognition of its heterogeneity has driven a paradigm shift toward precision medicine, tailoring multimodal strategies to the dominant pain mechanism, critical challenges persist. These include difficulty in identifying treatable root causes, limited long-
Abstract by Xiaofeng Dai; Chongxiang Wang; Ping Jiang; Xiaopeng Mei, MedComm (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/mco2.70685