Negative / Null Result ReportOpen accessMedicine· cited by 79

Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression

Howard R. Weeks; Scott C. Tadler; Kelly W. Smith; Eli Iacob; Mikala Saccoman; Andrea T. White; Joshua Landvatter; Gordon J. Chelune · 2013 · PLoS ONE

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

The finding, in one line

“Subsequent studies altered drug, dose or number of treatments, and failed to replicate this success, halting research on isoflurane's antidepressant effects for a decade.”

Abstract

BACKGROUND: Many patients have serious depression that is nonresponsive to medications, but refuse electroconvulsive therapy (ECT). Early research suggested that isoflurane anesthesia may be an effective alternative to ECT. Subsequent studies altered drug, dose or number of treatments, and failed to replicate this success, halting research on isoflurane's antidepressant effects for a decade. Our aim was to re-examine whether isoflurane has antidepressant effects comparable to ECT, with less adverse effects on cognition. METHOD: Patients with medication-refractory depression received an average

Abstract by Howard R. Weeks; Scott C. Tadler; Kelly W. Smith; Eli Iacob; Mikala Saccoman; Andrea T. White; Joshua Landvatter; Gordon J. Chelune, PLoS ONE (2013) — licensed CC BY 4.0.

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