Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation
Matthias Diebold; Hannes Vietzen; Andreas Heinzel; Susanne Haindl; Carsten T. Herz; Katharina A. Mayer; Konstantin Doberer; Alexander Kainz · 2023 · American Journal of Transplantation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Antibody-mediated rejection (ABMR) is a leading cause of graft failure. Emerging evidence suggests a significant contribution of natural killer (NK) cells to microvascular inflammation (MVI). We investigated the influence of genetically determined NK cell functionality on ABMR development and activity. The study included 86 kidney transplant recipients subjected to systematic biopsies triggered by donor-specific antibody detection. We performed killer immunoglobulin-like receptor typing to predict missing self and genotyped polymorphisms determining NK cell functionality (FCGR3AV/F158 [rs39699
Abstract by Matthias Diebold; Hannes Vietzen; Andreas Heinzel; Susanne Haindl; Carsten T. Herz; Katharina A. Mayer; Konstantin Doberer; Alexander Kainz, American Journal of Transplantation (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.ajt.2023.12.005