Replicability of structural brain alterations associated with general psychopathology: evidence from a population-representative birth cohort
Adrienne L. Romer; Annchen R. Knodt; Maria L. Sison; David Ireland; Renate Houts; Sandhya Ramrakha; Richie Poulton; Ross Keenan · 2019 · Molecular Psychiatry
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Transdiagnostic research has identified a general psychopathology factor-often called the 'p' factor-that accounts for shared variation across internalizing, externalizing, and thought disorders in diverse samples. It has been argued that the p factor may reflect dysfunctional thinking present in serious mental illness. In support of this, we previously used a theory-free, data-driven multimodal neuroimaging approach to find that higher p factor scores are associated with structural alterations within a cerebello-thalamo-cortical circuit (CTCC) and visual association cortex, both of which are
Abstract by Adrienne L. Romer; Annchen R. Knodt; Maria L. Sison; David Ireland; Renate Houts; Sandhya Ramrakha; Richie Poulton; Ross Keenan, Molecular Psychiatry (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41380-019-0621-z