Regulation of LEAP2 by insulin and glucagon in mice and humans
Valdemar Brimnes Ingemann Johansen; Anna Katrina Jógvansdóttir Gradel; Stephanie Kjærulff Holm; Joyceline Cuenco; Christoffer Merrild; Natalia Petersen; Damien Demozay; Bharath K. Mani · 2025 · Cell Reports Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the ghrelin receptor, countering ghrelin's effects on cell signaling and feeding. However, despite an emerging interest in LEAP2's…
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Metadata source: OpenAlex · DOI 10.1016/j.xcrm.2025.101996