Tavapadon as Adjunctive Treatment for Parkinson Disease
Hubert H. Fernandez; S. H. Isaacson; Robert A. Hauser; Pinky Agarwal; William Ondo; Ariane Park; D. Kremens; Matthew Leoni · 2026 · JAMA Neurology
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Importance: Development of motor fluctuations is common in people with Parkinson disease (PD) treated with oral levodopa, and currently available dopamine (D) agonists adjunctive to levodopa offer additional motor control but may increase…
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Metadata source: OpenAlex · DOI 10.1001/jamaneurol.2026.0577