Biological and clinical insights from a randomized phase 2 study of an anti-oncostatin M monoclonal antibody in systemic sclerosis.
Denton CP; Del Galdo F; Khanna D; Vonk MC; Chung L; Johnson SR; Varga J; Furst DE · 2022 · Rheumatology (Oxford, England)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Objectives The cytokine oncostatin M (OSM) is implicated in the pathology of SSc. Inhibiting OSM signalling using GSK2330811 (an anti-OSM monoclonal antibody) in patients with SSc has the potential to slow or stop the disease process.…
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Metadata source: Europe PMC · DOI 10.1093/rheumatology/keac300