Post hoc analysis of a randomised controlled trial: effect of vitamin D supplementation on circulating levels of desmosine in COPD
Rob Janssen; Jef Serré; Ianthe Piscaer; Ruben Zaal; Henny van Daal; Carolien Mathyssen; Pieter Zanen; Jody M.W. van den Ouweland · 2020 · ERJ Open Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background Vitamin D supplementation lowers exacerbation frequency in severe vitamin D-deficient patients with COPD. Data regarding the effect of vitamin D on elastin degradation are lacking. Based on the vitamin's anti-inflammatory properties, we hypothesised that vitamin D supplementation reduces elastin degradation, particularly in vitamin D-deficient COPD patients. We assessed the effect of vitamin D status and supplementation on elastin degradation by measuring plasma desmosine, a biomarker of elastin degradation. Methods Desmosine was measured every 4 months in plasma of 142 vitamin D-na
Abstract by Rob Janssen; Jef Serré; Ianthe Piscaer; Ruben Zaal; Henny van Daal; Carolien Mathyssen; Pieter Zanen; Jody M.W. van den Ouweland, ERJ Open Research (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1183/23120541.00128-2019