The beneficial effect of probiotics in the prevention of irinotecan-induced diarrhea in colorectal cancer patients with colostomy: a pooled analysis of two probiotic trials (Probio-SK-003 and Probio-SK-005) led by Slovak Cooperative Oncology Group
Michal Mego; Barbora Judita Kasperová; Jozef Chovanec; Radoslav Danis; Mária Rečková; Branislav Bystrický; Peter Konkolovsky; Silvia Jurišová · 2024 · Frontiers in Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background: Probiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in metastatic colorectal cancer (CRC) patients. Methods: This combined analysis included 46 patients with CRC enrolled in the Probio-SK-003 (NCT01410955) and 233 patients from Probio-SK-005 (NCT02819960) starting a new line of irinotecan-based therapy with identical eligibility criteria. Patients we
Abstract by Michal Mego; Barbora Judita Kasperová; Jozef Chovanec; Radoslav Danis; Mária Rečková; Branislav Bystrický; Peter Konkolovsky; Silvia Jurišová, Frontiers in Oncology (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fonc.2024.1438657