Prerequisites for the acquisition of mammalian pathogenicity by influenza A virus with a prototypic avian PB2 gene
Chung-Young Lee; Se-Hee An; Il Hwan Kim; Du‐Min Go; Dae-Yong Kim; Jun‐Gu Choi; Youn‐Jeong Lee; Jae‐Hong Kim · 2017 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1, and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated. Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here, we demonstrated that key amino acid mutations (I66M, I109V, and I133V, collectively referred to as MVV) of this prototypic avian PB2 increase the replica
Abstract by Chung-Young Lee; Se-Hee An; Il Hwan Kim; Du‐Min Go; Dae-Yong Kim; Jun‐Gu Choi; Youn‐Jeong Lee; Jae‐Hong Kim, Scientific Reports (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-017-09560-z