Daily supplementation of D-ribose shows no therapeutic benefits in the MHC-I transgenic mouse model of inflammatory myositis.
William Coley; Sree Rayavarapu; Jack H van der Meulen; Ayyappa S Duba; Kanneboyina Nagaraju · 2013 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Current treatments for idiopathic inflammatory myopathies (collectively called myositis) focus on the suppression of an autoimmune inflammatory response within the skeletal muscle. However, it has been observed that there is a poor correlation between the successful suppression of muscle inflammation and an improvement in muscle function. Some evidence in the literature suggests that metabolic abnormalities in the skeletal muscle underlie the weakness that continues despite successful immunosuppression. We have previously shown that decreased expression of a purine nucleotide cycle
Abstract by William Coley; Sree Rayavarapu; Jack H van der Meulen; Ayyappa S Duba; Kanneboyina Nagaraju, PLoS ONE (2013) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0065970