A hitchhiker’s guide to cerebrospinal fluid biomarkers for neuro-oncology
Cécile Riviere-Cazaux; Michael B. Keough; Jeffrey Zuccato; Rahul Kumar; Sebastian C Schulz; Arthur E. Warrington; Michael W. Ruff; Benjamin M. Ellingson · 2024 · Neuro-Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cerebrospinal fluid (CSF) has emerged as a valuable liquid biopsy source for glioma biomarker discovery and validation. CSF produced within the ventricles circulates through the subarachnoid space, where the composition of glioma-derived analytes is influenced by the proximity and anatomical location of sampling relative to tumor, in addition to underlying tumor biology. The substantial gradients observed between lumbar and intracranial CSF compartments for tumor-derived analytes underscore the importance of sampling site selection. Moreover, radiographic features, such as tumor-CSF contact an
Abstract by Cécile Riviere-Cazaux; Michael B. Keough; Jeffrey Zuccato; Rahul Kumar; Sebastian C Schulz; Arthur E. Warrington; Michael W. Ruff; Benjamin M. Ellingson, Neuro-Oncology (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/neuonc/noae276