Ratcheting down the virulence of SARS‐CoV‐2 in the COVID‐19 pandemic
Adam Brufsky; Michael T. Lotze · 2020 · Journal of Medical Virology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Muller's ratchet1 predicts that when mutation rates are high and a significant proportion of mutations are deleterious, a kind of irreversible ratchet mechanism will gradually decrease the mean fitness of small populations of asexual organisms.2 In cell culture, serial passage of genetically bottlenecked vesicular stomatitis virus, which grew quite rapidly on HeLa cells, severely reduced in fitness and virulence within 20 passages in a novel BHK host cell.2 Genetic bottlenecks are likely important in intraspecies viral transmission.3 RNA-based viruses are particularly prone to repeated bottlen
Abstract by Adam Brufsky; Michael T. Lotze, Journal of Medical Virology (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/jmv.26067