Negative / Null Result ReportOpen accessMedicine· cited by 10

Climate change and hyponatremia‐related hospital admissions in people with focal epilepsy exposed to carbamazepine or its derivatives

Francesco Fortunato; Francesco D’Amico; Anny Votano; Ilaria Sammarra; Environmental Climate Observatory Group – CNR‐ISAC Lamezia Terme; Michele Trimboli; Medine I. Gulcebi; James D. Mills · 2025 · Epilepsia

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

OBJECTIVE: To estimate the proportion of individuals with focal epilepsy treated with at least one among carbamazepine (CBZ), oxcarbazepine (OXC), or eslicarbazepine (ESL), who were hospitalized due to hyponatremia-related symptoms in 2024, and to test the hypothesis that there is an association with climatic variables. METHODS: We undertook a prospective study in which people with focal epilepsy treated with at least one of the target drugs and at least one attendance in 2024 formed the study cohort. Individuals who were admitted or seen as outpatients for hyponatremia in 2024 were considered

Abstract by Francesco Fortunato; Francesco D’Amico; Anny Votano; Ilaria Sammarra; Environmental Climate Observatory Group – CNR‐ISAC Lamezia Terme; Michele Trimboli; Medine I. Gulcebi; James D. Mills, Epilepsia (2025) — licensed CC BY 4.0.

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