Pre- and post-operative anti-PD-L1 plus anti-angiogenic therapies in mouse breast or renal cancer models of micro- or macro-metastatic disease
Florence T.H. Wu; Ping Xu; Annabelle Chow; Shan Man; Janna Krüger; Kabir A. Khan; Marta Pàez‐Ribes; Elizabeth Pham · 2018 · British Journal of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
There are phase 3 clinical trials underway evaluating anti-PD-L1 antibodies as adjuvant (postoperative) monotherapies for resectable renal cell carcinoma (RCC) and triple-negative breast cancer (TNBC); in combination with antiangiogenic VEGF/VEGFR2 inhibitors (e.g., bevacizumab and sunitinib) for metastatic RCC; and in combination with chemotherapeutics as neoadjuvant (preoperative) therapies for resectable TNBC. This study investigated these and similar clinically relevant drug combinations in highly translational preclinical models of micro- and macro-metastatic disease that spontaneously de
Abstract by Florence T.H. Wu; Ping Xu; Annabelle Chow; Shan Man; Janna Krüger; Kabir A. Khan; Marta Pàez‐Ribes; Elizabeth Pham, British Journal of Cancer (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41416-018-0297-1