Photodynamic therapy changes tumour immunogenicity and promotes immune-checkpoint blockade response, particularly when combined with micromechanical priming
Catarina S. Lobo; Maria Inês P. Mendes; Diogo A. Pereira; Lígia C. Gomes‐da‐Silva; Luı́s G. Arnaut · 2023 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Photodynamic therapy (PDT) with redaporfin stimulates colon carcinoma (CT26), breast (4T1) and melanoma (B16F10) cells to display high levels of CD80 molecules on their surfaces. CD80 overexpression amplifies immunogenicity because it increases same cell (cis) CD80:PD-L1 interactions, which (i) disrupt binding of T-cells PD-1 inhibitory receptors with their ligands (PD-L1) in tumour cells, and (ii) inhibit CTLA-4 inhibitory receptors binding to CD80 in tumour cells. In some cancer cells, redaporfin-PDT also increases CTLA-4 and PD-L1 expressions and virtuous combinations between PDT and immune
Abstract by Catarina S. Lobo; Maria Inês P. Mendes; Diogo A. Pereira; Lígia C. Gomes‐da‐Silva; Luı́s G. Arnaut, Scientific Reports (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-023-38862-8