Hydroxychloroquine and short-course radiotherapy in elderly patients with newly diagnosed high-grade glioma: a randomized phase II trial
Lucy Brazil; Angela Swampillai; Ka Man Mak; Darren Edwards; Pavlina Mesiri; Laura Clifton‐Hadley; Richard Shaffer; Joanne Lewis · 2020 · Neuro-Oncology Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Effective treatment for patients at least 70 years with newly diagnosed glioblastoma remains challenging and alternatives to conventional cytotoxics are appealing. Autophagy inhibition has shown promising efficacy and safety in small studies of glioblastoma and other cancers. METHODS: We conducted a randomized phase II trial to compare radiotherapy with or without hydroxychloroquine (2:1 allocation). Patients aged at least 70 years with newly diagnosed high-grade glioma deemed suitable for short-course radiotherapy with an ECOG performance status of 0-1 were included. Radiotherapy
Abstract by Lucy Brazil; Angela Swampillai; Ka Man Mak; Darren Edwards; Pavlina Mesiri; Laura Clifton‐Hadley; Richard Shaffer; Joanne Lewis, Neuro-Oncology Advances (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/noajnl/vdaa046