Negative / Null Result ReportOpen accessMedicine· cited by 49

Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts

Tácia Tavares Aquinas Liguori; Gabriel Romero Liguori; Luíz Felipe Pinho Moreira; Martin C. Harmsen · 2018 · Scientific Reports

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Transforming growth factor-β1 (TGF-β1) is a potent inducer of fibroblast to myofibroblast differentiation and contributes to the pro-fibrotic microenvironment during cardiac remodeling. Fibroblast growth factor-2 (FGF-2) is a growth factor secreted by adipose tissue-derived stromal cells (ASC) which can antagonize TGF-β1 signaling. We hypothesized that TGF-β1-induced cardiac fibroblast to myofibroblast differentiation is abrogated by FGF-2 and ASC conditioned medium (ASC-CMed). Our experiments demonstrated that TGF-β1 treatment-induced cardiac fibroblast differentiation into myofibroblasts, as

Abstract by Tácia Tavares Aquinas Liguori; Gabriel Romero Liguori; Luíz Felipe Pinho Moreira; Martin C. Harmsen, Scientific Reports (2018) — licensed CC BY 4.0.

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