TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection
Meisam Yousefi; Wai Suet Lee; Biaoguo Yan; Liang Cui; Cythia Lingli Yong; Xin Yap; Kwan Sing Leona Tay; Wenjie Qiao · 2022 · PLoS Pathogens
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Transmembrane Protein 41B (TMEM41B) and Vacuole Membrane Protein 1 (VMP1) are two ER-associated lipid scramblases that play a role in autophagosome formation and cellular lipid metabolism. TMEM41B is also a recently validated host factor required by flaviviruses and coronaviruses. However, the exact underlying mechanism of TMEM41B in promoting viral infections remains an open question. Here, we validated that both TMEM41B and VMP1 are essential host dependency factors for all four serotypes of dengue virus (DENV) and human coronavirus OC43 (HCoV-OC43), but not chikungunya virus (CHIKV). While
Abstract by Meisam Yousefi; Wai Suet Lee; Biaoguo Yan; Liang Cui; Cythia Lingli Yong; Xin Yap; Kwan Sing Leona Tay; Wenjie Qiao, PLoS Pathogens (2022) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.ppat.1010763