Human microglial transitions at the Aβ–tau inflection point associate with divergent pathways to dementia and resilience
Ashley Lu; Wei-Ting Chen; Maria Dalby; Diego Sáinz García; Marisa Vanheusden; Luuk E. de Vries; Veerle van Lieshout; Araks Martirosyan · 2026 · Nature Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Alzheimer's disease (AD) is not an inevitable outcome of pathology but a dynamic process shaped by how brain cells respond to amyloid-β (Aβ) and tau. To disentangle these responses, we combined spatial transcriptomics and single-nucleus RNA sequencing of the superior frontal cortex from octogenarians living with or without dementia and from cognitively intact centenarians with comparable Aβ accumulation. We identified six distinct tissue domains representing a spatial pathological continuum of AD, with a key inflection point marked by a shift from Aβ-associated inflammatory changes to tau-asso
Abstract by Ashley Lu; Wei-Ting Chen; Maria Dalby; Diego Sáinz García; Marisa Vanheusden; Luuk E. de Vries; Veerle van Lieshout; Araks Martirosyan, Nature Medicine (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41591-026-04393-8