Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo
Federica Albanese; Daniela Mercatelli; Luca Finetti; Giulia Lamonaca; Sara Pizzi; Derya R. Shimshek; Giovanni Bernacchia; Michele Morari · 2021 · Neurobiology of Disease
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease. LRRK2 modulates the autophagy-lysosome pathway (ALP), a clearance process subserving the quality control of cellular proteins and organelles. Since…
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Metadata source: OpenAlex · DOI 10.1016/j.nbd.2021.105487