Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab
James L. Alexander; Hajir Ibraheim; Bhavisha P. Sheth; Jessica Little; Muhammad Khan; Camellia Richards; Nikki Hunter; Dharmisha Chauhan · 2021 · Journal for ImmunoTherapy of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
INTRODUCTION: Immune checkpoint inhibitors (CPIs) have changed the treatment landscape for many cancers, but also cause severe inflammatory side effects including enterocolitis. CPI-induced enterocolitis is treated empirically with corticosteroids, and infliximab (IFX) is used in corticosteroid-refractory cases. However, robust outcome data for these patients are scarce. METHODS: We conducted a multicenter (six cancer centers), cohort study of outcomes in patients treated with IFX for corticosteroid-refractory CPI-induced enterocolitis between 2007 and 2020. The primary outcome was corticoster
Abstract by James L. Alexander; Hajir Ibraheim; Bhavisha P. Sheth; Jessica Little; Muhammad Khan; Camellia Richards; Nikki Hunter; Dharmisha Chauhan, Journal for ImmunoTherapy of Cancer (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1136/jitc-2021-002742