Mycotoxins and the Intestinal Epithelium: From Barrier Injury to Stem Cell Dysfunction
Wenying Huo; Yingying Qiao; Xiangru He; Cailing Wang; Ruiqing Li; Long Che; Enkai Li · 2025 · Toxins
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mycotoxins are toxic secondary metabolites produced by filamentous fungi that contaminate agricultural commodities, posing risks to food safety, animal productivity, and human health. The gastrointestinal tract is the first and most critical site of exposure, where the intestinal epithelium functions as both a physical and immunological barrier against luminal toxins and pathogens. While extensive research has demonstrated that mycotoxins disrupt epithelial integrity through tight junction impairment, oxidative stress, apoptosis, and inflammation, their effects on the intestinal stem cell (ISC
Abstract by Wenying Huo; Yingying Qiao; Xiangru He; Cailing Wang; Ruiqing Li; Long Che; Enkai Li, Toxins (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/toxins17110534