Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003.
Gondi V; Pugh SL; Mehta MP; Wefel JS; Tomé WA; Sun AY; Grecula J; Redmond KJ · 2025 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Purpose Hippocampal avoidance (HA) during therapeutic whole-brain radiotherapy reduces the risk of neurocognitive function (NCF) toxicity in patients with brain metastasis. This trial hypothesized that HA during prophylactic cranial…
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Metadata source: Europe PMC · DOI 10.1200/jco-25-00221