A novel strategy to attenuate porcine reproductive and respiratory syndrome virus by inhibiting viral replication in the target pulmonary alveolar macrophages via hematopoietic-specific miR-142
Shaoyuan Tan; Weixin Wu; Xinna Ge; Yongning Zhang; Jun Han; Xin Guo; Lei Zhou; Hanchun Yang · 2023 · One Health Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen for the global pork industry. Although modified live virus (MLV) vaccines are commonly used for PRRSV prevention and control, they still carry a risk of infecting the host and replicating in target cells, thereby increasing the likehood of virus recombination and reversion to virulence. In this study, we inserted the target sequence of miR-142 into the nsp2 hypervariable region of PRRSV to inhibit viral replication in its host cells of pigs, with the aim of achieving virus attenuation. The chimeri
Abstract by Shaoyuan Tan; Weixin Wu; Xinna Ge; Yongning Zhang; Jun Han; Xin Guo; Lei Zhou; Hanchun Yang, One Health Advances (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s44280-023-00002-2