Recursive seed amplification detects distinct α-synuclein strains in cerebrospinal fluid of patients with Parkinson’s disease
Stefan Bräuer; Iñaki Schniewind; Elisabeth Dinter; Björn Falkenburger · 2025 · Acta Neuropathologica Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with a wide range of clinical phenotypes. Pathologically, it is characterized by neuronal inclusions containing misfolded, fibrillar alpha-synuclein (aSyn). Prion-like properties of aSyn contribute to the spread of aSyn pathology throughout the nervous system as the disease progresses. Utilizing these properties, seed amplification assays (SAA) enable the detection of aSyn pathology in living patients. We hypothesized that structurally distinct aSyn aggregates, or strains, may underlie the clinical heterogeneity of PD. To t
Abstract by Stefan Bräuer; Iñaki Schniewind; Elisabeth Dinter; Björn Falkenburger, Acta Neuropathologica Communications (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s40478-024-01923-8