Insulin therapy improves bone microstructure and material properties without restoring whole-bone strength in male insulin-deficient Akita mice.
Toillon I; Badoud I; Ferrari S; Gerbaix M · 2026 · Bone
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Type 1 diabetes is associated with increased fracture risk, yet the respective contributions of insulin deficiency and replacement to skeletal fragility remain poorly understood. Using insulin-deficient male Akita mice, we characterized…
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Metadata source: Europe PMC · DOI 10.1016/j.bone.2026.117971