Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo.
Broadley D; Le Riche A; Yu Y; El-Bacha H; Erdmann H; Jimenez F; Geyfman M; Poloso N · 2026 · International journal of molecular sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Androgen receptor (AR) signaling plays a key role in male pattern baldness. We investigated whether targeting Dickkopf 1 ( DKK1 ) and Secreted frizzled-related protein 1 ( SFRP1 ), two AR-regulated genes, offers a novel therapeutic…
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Metadata source: Europe PMC · DOI 10.3390/ijms27041815