Mutations in the WFYY motif alter human PrimPol activity: structural insights from atomistic MD simulations.
Sudhakar S; Mishra VK; Harikrishna S; Naskar S; Pradeepkumar PI · 2026 · Physical chemistry chemical physics : PCCP
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Human PrimPol (hPrimPol) is the primase and polymerase enzyme involved in reinitiating DNA replication at stalled replication forks. The hPrimPol mutants are linked to multiple ophthalmoplegic conditions and mitochondriopathies. The WFYY…
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Metadata source: Europe PMC · DOI 10.1039/d6cp00786d