Failed Experiment ReportOpen accessMedicine

Lupeol and pristimerin do not inhibit activation of the human sperm CatSper Ca(2+)-channel [version 2; peer review: 2 approved, 1 approved with reservations]

Christian Marcus Pedersen; Anders Rehfeld · 2022 · F1000Research

WASTE classifies this as Failed Experiment Report · AI classification, approximate

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The finding, in one line

“While the original study on this topic found these triterpenoids to act as potent inhibitors of human CatSper, subsequent studies have failed to replicate such an inhibitory effect.”

Abstract

Opposing findings have been published on the regulation of the sperm-specific Ca2+ channel CatSper (cation channel of sperm) in human sperm cells by the plant triterpenoids lupeol and pristimerin. While the original study on this topic found these triterpenoids to act as potent inhibitors of human CatSper, subsequent studies have failed to replicate such an inhibitory effect. It has been suggested that these issues could in part be due to purity issues and/or batch variation between the plant-derived extracts of lupeol and pristimerin obtained for the studies. The aim of this study was to eluc

Abstract by Christian Marcus Pedersen; Anders Rehfeld, F1000Research (2022) — licensed CC BY 4.0.

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