Negative / Null Result ReportOpen accessMedicine· cited by 11

Interfering With DNA Decondensation as a Strategy Against Mycobacteria

Enzo M. Scutigliani; Edwin R. Scholl; Anita E. Grootemaat; Sadhana Khanal; Jakub Kochan; Przemek M. Krawczyk; Eric A. Reits; Atefeh Garzan · 2018 · Frontiers in Microbiology

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multi-drug resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of Mycobacterium tuberculosis. We demonstrate that the DNA of M. tuberculosis can condense under stressful conditions such as starvation and antibiotic trea

Abstract by Enzo M. Scutigliani; Edwin R. Scholl; Anita E. Grootemaat; Sadhana Khanal; Jakub Kochan; Przemek M. Krawczyk; Eric A. Reits; Atefeh Garzan, Frontiers in Microbiology (2018) — licensed CC BY 4.0.

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