A Multicentre Open-Label Safety and Efficacy Study of Tetrodotoxin for Cancer Pain
Neil A. Hagen; Bernard Lapointe; May Ong-Lam; Benoit Dubuc; David Walde; Bruno Gagnon; Robin Love; Ravi Kumar Goel · 2011 · Current Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Cancer pain is highly prevalent, and existing treatments are often insufficient to provide adequate relief. OBJECTIVES: We assessed the long-term safety and efficacy of subcutaneous tetrodotoxin treatment in reducing the intensity of chronic cancer-related pain. METHODS: In this multicentre open-label longitudinal trial, 30 μg tetrodotoxin was administered subcutaneously twice daily for 4 days in a heterogeneous cohort of patients with persistent pain despite opioids and other analgesics. "Responder" was defined as a mean reduction of 30% or more in pain intensity from baseline; an
Abstract by Neil A. Hagen; Bernard Lapointe; May Ong-Lam; Benoit Dubuc; David Walde; Bruno Gagnon; Robin Love; Ravi Kumar Goel, Current Oncology (2011) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3747/co.v18i3.732