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A Comparative Analysis of Serum Sodium Level Utilizing Direct and Indirect Ion Selective Electrode in Critically Ill Patients with Hypoalbuminemia: Methodological Insights and Clinical Implications

Rukhsana Tumrani; S. Sabahat Haider; Mehvish Sana · 2024 · Pakistan Journal of Medical Research

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Abstract

Background: Serum electrolytes are one of the most frequently requested tests in patients from critical care settings. Methodsfor estimation of serum electrolytes include direct and indirect ion selective electrode (ISE). In case of indirect ISE, the pre-analytical dilution step can result in pseudonormonatremia or pseudohypernatremia in setting of hypoalbuminemia. Discrepancy in sodium results can lead to the misdiagnosis and mismanagement of critically ill patients. Objective: To evaluate the difference of mean serum sodium level measured by direct and indirect ISE in critically ill patients

Abstract by Rukhsana Tumrani; S. Sabahat Haider; Mehvish Sana, Pakistan Journal of Medical Research (2024) — licensed CC BY 4.0.

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