Negative / Null Result ReportOpen accessMedicine· cited by 16

The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study

Anna Kankaanpää; Asko Tolvanen; Laura Joensuu; Katja Waller; Aino Heikkinen; Jaakko Kaprio; Miina Ollikainen; Elina Sillanpää · 2025 · European Journal of Epidemiology

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

OBJECTIVES: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association. METHODS: Study participants were twins from the older Finnish Twin Cohort (n = 22,750; 18-50 years at baseline). LTPA was assessed using questionnaires in 1975, 1981 and 1990. The mortality follow-up lasted until 2020 and biol

Abstract by Anna Kankaanpää; Asko Tolvanen; Laura Joensuu; Katja Waller; Aino Heikkinen; Jaakko Kaprio; Miina Ollikainen; Elina Sillanpää, European Journal of Epidemiology (2025) — licensed CC BY 4.0.

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