Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors
Deborah Ayeni; Braden Miller; Alexandra Kuhlmann; Ping‐Chih Ho; Camila Robles-Oteíza; Mmaserame Gaefele; Stellar Levy; Fernando J. de Miguel · 2019 · Journal for ImmunoTherapy of Cancer
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) like erlotinib are effective for treating patients with EGFR mutant lung cancer; however, drug resistance inevitably emerges. Approaches to combine immunotherapies and targeted therapies to overcome or delay drug resistance have been hindered by limited knowledge of the effect of erlotinib on tumor-infiltrating immune cells. METHODS: Using mouse models, we studied the immunological profile of mutant EGFR-driven lung tumors before and after erlotinib treatment. RESULTS: We found that erlotinib triggered the re
Abstract by Deborah Ayeni; Braden Miller; Alexandra Kuhlmann; Ping‐Chih Ho; Camila Robles-Oteíza; Mmaserame Gaefele; Stellar Levy; Fernando J. de Miguel, Journal for ImmunoTherapy of Cancer (2019) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s40425-019-0643-8