Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications
Sharmin Akter; Rajesh Madhuvilakku; Anik Kumar Kar; Irin Sultana Nila; Pengda Liu; Hiroyuki Inuzuka; Wenyi Wei; Yonggeun Hong · 2026 · Signal Transduction and Targeted Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation of redox signaling-driven by genetic mutations, epigenetic alterations, and posttranscriptional or posttranslational modifications-plays a central role in malignant transformation and cancer progression. Cancer cells typically exhibit elevated basal ROS levels due to increased metabolic activity, mitochondrial dysfunction, and oncogene activation. This mode
Abstract by Sharmin Akter; Rajesh Madhuvilakku; Anik Kumar Kar; Irin Sultana Nila; Pengda Liu; Hiroyuki Inuzuka; Wenyi Wei; Yonggeun Hong, Signal Transduction and Targeted Therapy (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41392-026-02583-x