PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Marwah Karim; Manjari Mishra; Chieh‐Wen Lo; Sirle Saul; H. Busra Cagirici; Manon Gourdelier; Luca Ghita; Amrita Ojha · 2025 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
In search for broad-spectrum antivirals, we discover a small molecule inhibitor, RMC-113, that potently suppresses the replication of multiple RNA viruses including SARS-CoV-2 in human lung organoids. We demonstrate selective inhibition of…
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-61759-1