Replication of H9 influenza viruses in the human ex vivo respiratory tract, and the influence of neuraminidase on virus release
Renee W. Y. Chan; Louisa Chan; Chris Ka Pun Mok; Jimmy C. C. Lai; Kin Pong Tao; Adebimpe Obadan; Michael C. W. Chan; Daniel R. Pérez · 2017 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
H9N2 viruses are the most widespread influenza viruses in poultry in Asia. We evaluated the infection and tropism of human and avian H9 influenza virus in the human respiratory tract using ex vivo respiratory organ culture. H9 viruses infected the upper and lower respiratory tract and the majority of H9 viruses had a decreased ability to release virus from the bronchus rather than the lung. This may be attributed to a weak neuraminidase (NA) cleavage of carbon-6-linked sialic acid (Sia) rather than carbon-3-linked Sia. The modified cleavage of N-acetlylneuraminic acid (Neu5Ac) and N-glycolylne
Abstract by Renee W. Y. Chan; Louisa Chan; Chris Ka Pun Mok; Jimmy C. C. Lai; Kin Pong Tao; Adebimpe Obadan; Michael C. W. Chan; Daniel R. Pérez, Scientific Reports (2017) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41598-017-05853-5