Efficacy, public health impact and optimal use of the Takeda dengue vaccine
Bethan Cracknell Daniels; Neil M. Ferguson; Ilaria Dorigatti · 2025 · Nature Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Dengue is the most common arboviral infection, causing substantial morbidity and mortality globally. The licensing of Qdenga, a second-generation vaccine developed by Takeda Pharmaceuticals, is therefore timely, but the potential public health impact of vaccination across transmission settings needs to be evaluated. To address this, we characterized Qdenga's efficacy profile using mathematical models calibrated to published clinical trial data and estimated the public health impact of routine vaccine use. We find that efficacy against both virologically confirmed dengue and hospitalization dep
Abstract by Bethan Cracknell Daniels; Neil M. Ferguson; Ilaria Dorigatti, Nature Medicine (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41591-025-03771-y